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It is made up of a variety of undifferentiated and terminally differentiated cells, such as stem cells and neural precursors, neurons, astrocytes, oligodendrocytes, microglia, pericytes, and vascular cells, which are attached to extracellular matrix (ECM) proteins that provide structural support, mechanical stability, metabolic coordination, and electrical activity [92]
If weight loss outpaces skin elasticity adaptation, the skin may appear looser initially, making cellulite more visible
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Gastrointestinal side effects may still occur even at reduced doses
Summary: GLP-1 medications do not lose their pharmacological effectiveness over time, but weight loss typically plateaus after 612 months due to metabolic adaptation and reduced energy requirements
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